Meet our doctoral candidate Tereza Jahodová
Meet our doctoral candidate: Tereza Jahodová from Czech Republic 🇨🇿
As part of the ECLectic network, she will focus on the point of care microfluidic tool development at Dynamic Biosensors (Germany 🇩🇪) under the supervision of prof. Alice Soldà.
She recently graduated at Uppsala University in Sweden, where she took an interest in investigating the biophysical properties of molecular interactions using the switchSENSE technology.
If you want to know more, click the button below and read her full bio and the description of her doctoral project in the dedicated section.
New paper in Chemical Science
Tunable electrochemiluminescence of TADF luminophores: manipulating efficiency and unveiling water-soluble emitters
Alessandro Fracassa, Francesco Calogero, Giulio Pavan, Pavlos Nikolaou, Andrea Fermi, Paola Ceroni, Francesco Paolucci, Pier Giorgio Cozzi, Thomas Scattolin, Nicola Demitri, Fabrizia Negri, Andrea Gualandi, Alessandro Aliprandi and Giovanni Valenti
Published in Chemical Science
Meet our doctoral candidate Abdulkadir Sadiq
Meet our doctoral candidate: Abdulkadir Sadiq from Nigeria 🇳🇬
He will investigate the analytical performances of a lab-on-a-chip device for bacteria quantification at Albert-Ludwigs-Universität Freiburg (Germany 🇩🇪) under the supervision of prof. Siegbert Rieg.
He recently completed his master’s degree in Biotechnology at the Universiti Malaya in Malaysia with a thesis focused on the anti-virulence potential of a synthesized compound against Staphylococcus aureus.
If you want to know more, click the button below and read his full bio and the description of his doctoral project in the dedicated section.
Meet our doctoral candidate Stephania Rodríguez Muiña
Meet our doctoral candidate: Stephania Rodríguez Muiña from Spain 🇪🇸
She will work on developing an integrated microfluidic platform for the multiplex detection of sepsis biomarkers at BCMaterials (Spain 🇪🇸) under the supervision of Professor F. Javier del Campo García.
Recently she developed a flexible electrochemical biosensor platform for cell culture monitoring at the CRNL and Laboratoire Ampère in Lyon.
If you want to know more, click the button below and read her full bio and the description of her doctoral project in the dedicated section.
New paper in Analytical and Bioanalytical Chemistry
Biosensing strategies using recombinant luminescent proteins and their use for food and environmental analysis
Fernando Pradanas-González, Marta García Cortés, Bettina Glahn-Martínez, Melisa del Barrio, Pablo Purohit, Elena Benito-Peña and Guillermo Orellana
New paper in Analytical and Bioanalytical Chemistry
Progress in synthetic biology and nanotechnology plays at present a major role in the fabrication of sophisticated and miniaturized analytical devices that provide the means to tackle the need for new tools and methods for environmental and food safety. Significant research efforts have led to biosensing experiments experiencing a remarkable growth with the development and application of recombinant luminescent proteins (RLPs) being at the core of this boost. Integrating RLPs into biosensors has resulted in highly versatile detection platforms. These platforms include luminescent enzyme-linked immunosorbent assays (ELISAs), bioluminescence resonance energy transfer (BRET)–based sensors, and genetically encoded luminescent biosensors. Increased signal-to-noise ratios, rapid response times, and the ability to monitor dynamic biological processes in live cells are advantages inherent to the approaches mentioned above. Furthermore, novel fusion proteins and optimized expression systems to improve their stability, brightness, and spectral properties have enhanced the performance and pertinence of luminescent biosensors in diverse fields. This review highlights recent progress in RLP-based biosensing, showcasing their implementation for monitoring different contaminants commonly found in food and environmental samples. Future perspectives and potential challenges in these two areas of interest are also addressed, providing a comprehensive overview of the current state and a forecast of the biosensing strategies using recombinant luminescent proteins to come.
Meet our doctoral candidate Wissal El Majdoub
Meet our doctoral candidate: Wissal El Majdoub from France 🇫🇷
She will work on developing a micro- and nano-channels platform for ECLectic at Stichting imec Nederland (The Netherlands 🇳🇱) under the supervision of Professor Klaus Mathwig.
She recently obtained a MEng degree in Chemistry from the Graduate School of Food Science, Materials Science, and Chemistry in Bordeaux (France 🇫🇷), where she focused on nano and microtechnologies, with a particular emphasis on addressing pressing health-related challenges.
If you want to know more, click the button below and read her full bio and the description of her doctoral project in the dedicated section.
Meet our doctoral candidate Luigi Dragonetti
Meet our doctoral candidate: Luigi Dragonetti from Italy 🇮🇹
He will work on developing a sample-to-answer biosensor based on the electrode switchable DNA based nanolever at Dublic City University (Ireland 🇮🇪) under the supervision of Professor Robert Forster.
He recently obtained his Master Degree at the University of Bologna (Italy 🇮🇹) with a thesis focusing on the production and characterization of metal thin films, developing operational skills in SECM and XPS techniques.
If you want to know more, click the button below and read his full bio and the description of his doctoral project in the dedicated section.
New paper in Electrochimica Acta
Electrocatalytic amplification of coreactant electrochemiluminescence using redox mediators
Sara Knežević, Emily Kerr, Giovanni Valenti, Francesco Paolucci, Paul S. Francis, Conor F. Hogan, Neso Sojic, Frédéric Kanoufi
Published in Electrochimica Acta
Electrochemiluminescence (ECL) has emerged as a sensitive analytical technique with a wide range of applications. While recent studies have begun to explore the role of redox mediators to facilitate ECL systems, this work extends these foundational insights by developing a comprehensive theoretical framework that supports, generalizes, and rationalizes mechanistic pathways borrowed from molecular electrocatalysis. This advancement is demonstrated through the electrocatalytic amplification of coreactant ECL within the [Ru(bpy)3]2+/TPrA system, utilizing a water-soluble redox-active Ir(III) complex as an electrocatalyst. Our investigation unveils previously uncharted mechanisms that enable the enhancement of Ru complex ECL at low electrode potentials, crucially without requiring the direct oxidation of [Ru(bpy)3]2+ or TPrA at the electrode, thus offering a deeper understanding of ECL activation through moelcular electrocatalysis. Through an integrated approach combining electrochemical analysis, spectroscopic investigation, and finite element modeling, we elucidate how the redox mediator critically modulates ECL efficiency by controlling the kinetics of radical species production and decay. The mediation by the Ir(III) complex not only governs the generation of TPrA radicals and excited [Ru(bpy)3]2+ states, thereby enhancing ECL intensity, but also the conditions under which ECL can be quenched. Further exploration of the mediator’s redox characteristics provides predictive insights into ECL behavior, underscoring the mediator’s redox potential as pivotal in determining ECL onset, peak potential, and intensity. This refined understanding paves the way for tailoring ECL systems for enhanced performance in analytical, imaging, and biomedical applications through the judicious selection of redox mediators.
Graphical abstract
Meet our doctoral candidate Elisa D'Arrigo
Meet our doctoral candidate: Elisa D’Arrigo from Italy 🇮🇹
Elisa D’Arrigo will work on ECL from small cells at University of Bordeaux (France 🇫🇷) under the supervision of Professor Neso Sojic.
Over the last year, she was employed as a research fellow in the laboratory of Cellular Chemistry and Functional Imaging at the Department of Chemistry “G. Ciamician” of Alma Mater Studiorum University of Bologna
If you want to know more, click the button below and read her full bio and the description of her doctoral project in the dedicated section.
Meet our doctoral candidate Nayla Takeuti
Meet our doctoral candidate: Nayla Takeuti from Brazil 🇧🇷
Nayla Takeuti will work on earth abundant metal and free metal water soluble compounds for ECL at University of Milan (Italy 🇮🇹) under the supervision of Professor Luisa De Cola.
She recently obtained her Master Degree at the University of São Paulo (Brazil) with a thesis on The Development of Platforms for Detection of Tuberculosis Biomarkers.
If you want to know more, click the button below and read her full bio and the description of her doctoral project in the dedicated section.