ECL mechanism insight

Home institution: University of Bologna, IT
Starting date: 1st of November

Objectives: The main objective of this PhD is to address, from the physical chemistry point of view, the factors governing the generation of ECL during so called co-reactant mechanism.

Expected Results: DC should be able to (i) identify the rate determining step for the ECL generation; (ii) propose new set of chemicals and (iii) dye doped silica nanoparticles synthesis and optimization.

Supervisor: Prof. Valenti Giovanni

DC background, experience and skills: Masters degree in chemistry, materials chemistry or subjects related to photochemistry, electrochemistry, biosensing and the use of fluorescence and confocal microscopy.

Biografia candidato

ECL-active dye doped C-dots

Home institution: CIC BiomaGUNE, ES
Starting date: 1st of September

Objectives: The main objective of this PhD is to design and characterize different carbon based nanoparticles (C-dots) as multimodal platforms able to i) provide the required redox process and enhanced ECL response using one single system and avoid the use of additional co-reactants; ii) introduce functional units to assist/enhance the recognition of biological targets; iii) improve biocompatibility and affordability of the ECL responsive component. In addition DC will prepared different graphene hybrids as ink for innovative ECL active electrode material.

Expected Results: DC should be able to (i) prepare and characterize multicolour carbon nanodots for ECL and (ii) preparation of modified carbon-based materials with ECL activity.

Supervisor: Prof. Maurizio Prato

DC background, experience and skills: Masters degree in chemistry, materials science or subjects related to organic synthesis, nanomaterials, nanotechnology characterization and functionalization.

Biografia candidato

Earth abundant metal and free metal water soluble compounds for ECL

Home institution: University of Milan, IT
Starting date: 1st of September

Objectives: The main objective of this PhD is to synthetize and the characterize of the compounds by standard techniques such as nuclear magnetic resonance (NMR) and mass spectrometry (MS). A deep photophysical characterization will be performed to correlate the molecular design with the spectroscopical properties.

Expected Results: DC should be able to (i) synthesis of molecular ECL luminophore with different structure, photophysical, electrochemical and ECL propriety.

Supervisor: Prof. Luisa De Cola

DC background, experience and skills: Masters degree in chemistry, materials science or subjects related to photochemistry, organic chemistry, synthesis and characterization.

Biografia candidato

ECL from small cells

Home institution: Université de Bordeaux, FR
Starting date: 1st of September

Objectives: The main objective of this PhD is to develop protocols for heterogeneous ECL assays. The DC will implement an analytical platform for ECL microscopy of the micro and nano-objects. We will image the attached bacterial cells, microcolonies and biofilms by ECL.

Expected Results: DC should be able to (i) study the ECL imaging in the functionalized nanochannels and (ii) to study the ECL microscopy of the bacterial cells, microcolonies and biofilms.

Supervisor: Prof. Neso Sojic

DC background, experience and skills: Masters degree in chemistry, materials science or subjects related to electrochemistry analytical chemistry.

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DNA based nanolever

Home institution: Dublin City University, IE
Starting date: 1st of September

Objectives: The main objective of this PhD is to develop novel electrochemiluminescence method for identification of the pathogen sub-type.

Expected Results: DC should be able to develop a sample-to-answer biosensor based on the electrode switchable DNA based nanolever. The commercial and clinical utility of the bacteria detection strategies will be assessed through comparative testing vs. the commercially available state-of-the-art in partner industries and hospitals.

Supervisor: Prof. Robert Forster

DC background, experience and skills: Masters degree in chemistry, materials science or subjects related to electrochemistry analytical chemistry.

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Micro- and nano-channels platform

Home institution: Stichting imec Nederland, NL
Starting date: 1st of September

Objectives: The main objective of this PhD is to develop an integrated nano- and micro-fluidic system for analyte detection by integration of microfluidic handling to precisely deliver reactants (luminophores and coreactants) and analytes to a reaction chamber/detection area. The DC will develop these microfluidic devices further to integrate handling and ECL sensing of bacterial cells.

Expected Results: DC should be able to (i) set up microfluidic demonstrator integrated with microfluidic pumping, novel electrodes, novel and optimized ECL protocols and compounds developed by participants, (ii) integrate a robust microfluidic sensing prototype to be used for real clinical testing.

Supervisor: Dr. Klaus Mathwig

DC background, experience and skills: Masters degree in materials chemistry, biomedical engineering, microfabrication or subjects related to microsensors, microfabrication, additive manufacturing, systems engineering  or industrial design.

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Selection and production of recombinant antibodies (rAb)

Home institution: Complutense University of Madrid, ES
Starting date: 1st of September

Objectives: The main objective of this PhD is to develop is the production of recombinant antibodies (rAb) using “phage display” techniques for biomarker analysis.

Expected Results: DC should be able to (i) select rAbs for selected biomarker analysis, (ii) functionalize biomimetic molecules with nanomaterial for ECL applications and (iii) characterize the novel selective recognition elements and assessment of their performance in bioassays for biomarker detection in clinical samples.

Supervisor: Prof. Elena Benito Peña

DC background, experience and skills: Masters degree in chemistry, biochemistry, biomedical engineering or subjects related to analytical chemistry and antibody selection.

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ECL microfluidic platform

Home institution: BCMaterials, ES
Starting date: 1st of September

Objectives: The main objective of this PhD is to develop an integrated microfluidic platform for the multiplex detection of sepsis biomarkers.

Expected Results: DC should be able to (i) demonstrate a microfluidic ECL-based system for the detection of sepsis protein biomarkers with integrated electrochemical electrodes and optical sensing, (ii) show a proof-of- concept demonstration of device operation from spiked serum samples and to test of platform in a clinical environment.

Supervisor: Prof. F. Javier del Campo García

DC background, experience and skills: Masters degree in materials chemistry, biomedical engineering, microfabrication or subjects related to microsensors, microfabrication, additive manufacturing, systems engineering or industrial design.

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Pathogen ID

Home institution: University of Freiburg, GER
Starting date: 1st of September

Objectives: The aim of this PhD project is to investigate the analytical performances of lab-on-a-chip device for bacteria quantification.

Expected Results: DC should be able to use the state-of-the-art technology for the sepsis diagnosis; assess of critical sensing parameters including limits of detection, reliability, reproducibility, selectivity and speed under different conditions mimicking real-life situations and using relevant microorganisms in different metabolic states and concentrations.

Supervisor: Prof. Siegbert Rieg

DC background, experience and skills: Masters degree in biochemistry, biotechnology, Medicine or subjects related to infectiology.

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Point of care microfluidic tool development

Home institution: Dynamic Biosensors, GER
Starting date: 1st of June

Objectives: The main objective of this PhD is to develop the integrated Sample to Answer Device for Sepsis Biomarker and Bacteria Analysis.

Expected Results: DC10 should be able to (i) engineer and assemble the ECL biochip for the photoinduced chemical reactions; (ii) evaluate the chip and device performance; (iii) test stability and reproducibility of the data; (iv) compare the performance of the prototype with the commercially available devices.

Supervisor: Dr. Alice Soldà

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