ECLectic will provide scientists having different expertise in materials chemistry, biosensor technology, nanotechnology and clinical medicine
with the opportunity to interact toward the development of nanomaterials and their integration within novel analytical devices for diagnostic applications,
with a focus on sepsis

WORLDWIDE NETWORK

ECLectic will promote high quality research training to 10 DCs across teams located in 7 European countries. Our training will be also supported by
researchers beyond the borders of the EU giving to ECLectic the opportunity to build a worldwide network and visibility.

Each of the DC will be recruited for a 36-month period to complete PhD projects involving different partners in close interdependency.

Work Packages

Coordination
and
Management

Lead Beneficiary: UniBo
Start Month – End Month: 1-48

Active Molecule and Nanomaterials ECL Luminophores

Lead Beneficiary: BiomaGUNE
Start Month – End Month: 7-42

Electrochemiluminescence Mechanism and Performance Optimisation

Lead Beneficiary: UBx
Start Month – End Month: 7-42

Microfluidic lab-on-a-chip biosensing

Lead Beneficiary: IMEC-NL
Start Month – End Month: 7-42

Multianalyte, Multiplexed Detection Strategies

Lead Beneficiary: DCU
Start Month – End Month: 7-42

Soft and Transferable
Skills Training

Lead Beneficiary: UCM
Start Month – End Month: 1-48

Dissemination and Communication

Lead Beneficiary: DBS and BCM
Start Month – End Month: 1-48

Main Network-Wide Training Events

Main Training Events & Conferences

Network Event 1 (WP5 and WP4)When: month 7, duration 4 days
Organized by: UKLFRWhere: Freiburg

This workshop will be organized after the recruitment of all the DCs. This four day workshop will harmonize all the participants with the required basic knowledge on medical device regulation, sepsis and bacterial infection. Key objectives are to highlight (i) the state of art and the future perspectives for sepsis diagnosis, (ii) medical device regulation, (iii) the impact of early diagnosis on patient and on the society and (iv) the overview of the user of the final device. This event will be organized by the UKLFR with the important contribution of the member of advisory board Prof Matthijs Kox and non-profit organization such as GSA and the ESCMID. At the end we will organize half a day team-building events in combination with some of the workshops that combine physical and intellectual activities to develop the cohesion of DC and advisors.


Network Event 2 (WP5 and WP2)When: month 10, duration: one-week
Organized by: UniBoWhere: Bologna

This one-week school will focus on innovative transduction techniques with biosensor application such as bioluminescence, chemiluminescence and particular emphasis to electrochemiluminescence. It will be composed of lectures given by industry experts on “real problems and challenges” and also lectures covering the fundamental aspects of the mechanism for the generation of the analytical signal. It will include lectures by invited scientists illustrating outstanding the most recent developments on the topic and the important role of nanomaterials in this fields. This event will be organized by UniBo in Bologna with important contribution of the photochemistry group lead by Prof Prodi. This school will be organized the week after the Photochemistry school typically organized by Photochemistry group. In this way the DCs with more oriented physical chemistry (such as DCs 1, 3 and 4) profile could extend their stay.


Network Event 3 (WP5 and WP2)When: month 13, 3 days
Organized by: UBxWhere: Bordeaux

This 3-day tutorial will present the fundamentals of ECL, the (bio)analytical applications and ECL microscopy. It will include hands-on demonstrations and lectures by invited experts in the field. The limitations and the perspectives of ECL (bio)assays and (bio)sensors will be presented with a special focus on the comparison with competing technologies.


Network Event 4 (WP5 and WP6)When: month 15, 2 days
Organized by: BCMWhere: Leioa

It will consist of three, two-day workshops and will take place during the last quarter of the programme, when they will be most useful for the DCs. The event will cover crucial presentation issues related to successful scientific writing, scientific publications, proposals writing and EU grants, including individual Marie Skłodowska-Curie actions. In addition, the workshop will also include round tables and discussion sessions on scientific misconduct and research integrity, MSCA Green Charter, open science, responsible research and innovation. All topics aim at increasing the DCs awareness about these issues and at decreasing the chances of the DCs being affected by them during their careers. Associated partner PSIQUADRO will deliver part of the programme, provide learning material to the DCs. External advisors will be invited and DCs will have the chance to meet and discuss with the experienced editors of the most important journals in chemistry (such as American Chemical Society).


Speakers(external advisors): Prof. Hua Cui (University of Science and Technology of China, China), Prof. Shelley D. Minteer (University of Utah, USA, editor of ACS) Prof Priscilla Baker (from University of the Western Cape, South Africa).


Network Event 5 (WP5 and WP1)When: month 19, 2 days
Organized by: DCU and UCMWhere: Dublin

This 2-days school will ensure all the participants have a high-level formation based on electrochemical methods and the latest developments and regulations of biosensor. Particular emphasis will be placed on defining the analytical challenge in sepsis- including clinician information needs, sample types, changes in LOD required over time, time-to-answer constraints, e.g., shift changes, reasonable expectations of nurses for carrying out the measurement etc. The state-of-the-art and the future perspectives for nanomaterials applied to the biosensors for early diagnosis, including an overview of the real biosensors application will be presented by both academic and industrial experts. An approach combining scientific expertise, applied economics, innovation, entrepreneurship, health care policies by leading institutions and regulatory context of health care device will also be introduced.


Network Event 6 (WP5 and WP3)When: month 25, 3 days
Organized by: IMEC-NL and WUWhere: Wageningen

This 3-day tutorial will mainly focus on microfluidic tools for biosensor application. It will include hands-on demonstrations and lectures by invited experts. In addition, finite element models implemented in COMSOL will be demonstrated and their verification/validation with experimental data emphasized.


Network Event 7 (WP5 and WP6)When: month 28, 4 days
Organized by: PSIQUADRO and UniBoWhere: Siena

This workshop is a four days intensive training on research communication and dissemination. The workshop is focused on training the DCs in successful dissemination campaigns with high impact; in familiarizing them with the operational tools, including video dissemination and production, and the best engagement practices for a strong presence in social media and in providing them with all necessary skills for developing successful business cases for the outcome of R&I projects. DCs will be able to create thriving awareness and engagement plans and develop strategic communication networks. In addition, a representative of European Young Chemistry Network (EYCN) will be invited for discuss about the importance of networking in Europe. In the last part DCs will prepare, supported by PSIQUADRO experts, a short MOOC focus on one thematic related to the project such as nanotechnologies, nanomedicine, biosensor or sepsis. At this stage the DC should be sufficiently established within the project topics to deal with “learning by teaching” approach. MOOC will be used for communication (see CO.4). PSIQUADRO will deliver part of the programme and provide learning material to DCs.


Speakers: A representative from the European Young Chemistry Network (EYCN) will be invited.

Network Event 8 (WP5)When: month 36, 3 days
Organized by: DBSWhere: Munich

This course provides DCs with the necessary skills to ensure the sustainability of the research results through exploitation opportunities, transfer of knowledge and entrepreneurship. The workshop will address the following objectives: to develop idea generation techniques, to know how to identify promising ideas for business or patenting, to become aware of individual entrepreneurial skills set and to know how to set up a business model. We will cover the following issues: generation of ideas, creativity techniques, entrepreneurial skills, rules of innovation, business ideas, start-up generation, business models; how to align the principles of open science with the protection of the results, etc. DCs will have the opportunity to interact directly with the young entrepreneurs from the other companies in the consortium, discuss their research, how to build their professional network and the challenges and needed steps to start a company. DCs will, during this NE, start the creation of a Virtual Company (EO.5) based on the project results and on the commercialization of the Sepsis biosensor. This process will start during this NE and will be finalize and presented during the final conference. We will take advantage of having medium company (DBS) involved in the project to address different aspects of business operations. An Outside Expert will be invited, who, together with our industrial partners will contribute to our DCs’ instruction on the process of patenting, confidential disclosure agreements, material transfer agreements, etc.


Speakers: Sabrina Conoci (UNIME), Amaia Zurutuza (Co-Founder Graphenea), Steffen Sedlak (Roche Diagnostics), Ralf Strasser (Co-Founder DBS), Windfuhr Michaela (Roche Diagnostics).

Network Event 9: Final conferenceWhen: month 42, 3 days

Will be organized as a symposium dedicated to biosensors during the regular meetings organized by the European Chemical Society (EuChems) or ISE International Electrochemical Society in the coming years (M42). At that time, all the DCs are expected to be able to present their final research results. These meetings will provide unique opportunities for the DCs to exchange knowledge with more experienced researchers and to expose their results to the whole scientific community. This event will be organized as a 3-days parallel symposium in the EuChems or ISE meeting enabling the presence of about 400 attendees, with the participation of scientists from the international scientific community and from industry. During this NE half of the day will be dedicated to the finalization and presentation (within the project participants) of the virtual company (D6.3).


Detailed secondments

DC1 – ECL mechanism insight

University of Bologna, IT
Secondments duration: 7 months

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UniBo

DC2 – ECL-active dye doped C-dots

CIC BiomaGUNE, ES
Secondments duration: 8 months

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BiomaGUNE

DC3 – Earth abundant metal and free metal water soluble compounds for ECL

University of Milan
Secondments duration: 7 months

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UMIL

DC4 – ECL from small cells

Université de Bordeaux
Secondments duration: 7 months

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UBx

DC5 – DNA based nanolever

Dublin City University, IE
Secondments duration: 7 months

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DCU

DC6 – Micro- and nano-channels platform

Stichting imec Nederland, NL
Secondments duration: 6 months

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IMEC-NL

DC7 – Selection and production of recombinant antibodies (rAb)

Complutense University of Madrid, ES
Secondments duration: 6 months

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UCM

DC8 – ECL microfluidic platform

BCMaterials, ES
Secondments duration: 10 months

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BCM

DC9 – Pathogen ID

University of Freiburg, GER
Secondments duration: 5 months

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UKLFR

DC10 – Point of care microfluidic tool development

Dynamic Biosensors, GER
Secondments duration: 6 months

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DBS